Positions

A postdoctoral fellow position is immediately available for a highly motivated trainee in biomedical science.

 

The laboratory studies the genetic determinants of blood cell development, homeostasis, and disease. We use molecular genetic, biochemical, and genome editing methodologies to perturb and observe blood cells. We have identified an erythroid enhancer of BCL11A as a critical determinant of fetal hemoglobin level and hemoglobin disorder clinical severity. We have developed a novel methodology, Cas9-mediated in situ saturating mutagenesis for high-throughput and high-resolution evaluation of noncoding element function. Our studies are meant to elucidate fundamental mechanisms of gene regulatory elements in their endogenous chromosomal environment and develop novel treatment strategies for blood disorders.

 

Prior experience in molecular and cell biology, genetics, biochemistry, gene therapy, hematopoiesis, systems biology, structural/chemical biology, and/or computational biology/bioinformatics is highly desirable. The candidate must be independent in scientific research and writing, self-motivated, ethical, team spirited, and must have exceptional laboratory, communication, organizational, and writing skills.

 

Please send a cover letter, CV, statement of research interest and contact information for three references via email to Daniel Bauer, MD PhD (daniel.bauer@childrens.harvard.edu), Division of Hematology/Oncology, Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA.

 

Boston Children’s Hospital is one of the top pediatric research centers in the world, and a major research and teaching affiliate of Harvard Medical School.